Researchers at N.C. A&T and UNC-Chapel Hill have been awarded a grant to investigate a particularly aggressive form of breast cancer. The team will work to determine the role of viral factors in the virulent nature of triple-negative breast cancer.
Triple-negative breast cancer represents 15% to 20% of breast carcinomas. It is prevalent in younger women, African American women, and in women with BRCA1 gene mutations. This type of cancer is very aggressive, has a poor prognosis, fails to respond to conventional therapy, and appears in many forms. The causes and molecular basis of this cancer are currently unknown, though multiple factors, including viruses, may be involved.
Specifically, this pilot study will investigate the prevalence of three particular types of viral genetic material in triple negative breast tumors and determine what role these passenger virus genetic materials play in the cancer’s malignant properties and survival.
The study will be led by Dr. Perpetua Muganda, professor of biology at N.C. A&T. The team will include Dr. Scott Harrison, assistant professor of biology at A&T; Dr. Dukka KC, assistant professor of computational science and engineering at A&T; and Dr. Jan Prins, professor of computer science at UNC-CH.