This week’s Department of Biology weekly seminar, Wednesday February 5, noon, Barnes Hall, Room 221:
Topic: New and Emerging Modes of Kinase Regulation
Speaker: Dr. Robert Newman, Assistant Professor of Biology
Abstract: Protein phosphorylation, mediated by protein kinases, is one of the most widespread regulatory mechanisms in eukaryotes. Inside the cell, kinases and their respective substrates are organized into complex phosphorylation networks that govern nearly all cellular processes.
To achieve signaling specificity in response to a given environmental stimulus, these networks must be precisely coordinated in cellular space and time. This involves regulation both at the level of kinase activity and at the level of substrate selection. Consequently, much effort has been devoted to understanding how these parameters are controlled inside cells.
In this seminar, we will explore two modes of kinase regulation, namely proteolytic processing and reversible oxidation, that have been relatively understudied but are emerging as important modulators of kinase activity in health and disease.