N.C. A&T grant of the month for April and May: $131,000 for cell-based toxicity assay-on-chip

The Sponsored Funding Report for April and May:

N.C. A&T received 26 grants totaling $2.61 million in April and May.

The complete list of grants received in April and May.

Logo for Semiconductor Research Corp.One highlight of the funding was a grant worth $131,000 from the Semiconductor Research Corp. to Dr. Shyam Aravamudhan of the Department of Nanoenigneering at the Joint School of Nanoscience and Nanoengineering.  Dr. Aravamudhan is an A&T faculty member.

The project: Cell-based toxicity assay-on-chip for the next-generation CMOS technology

The issue: It is recognized that the unique quantum properties of engineered nanomaterials (ENs) strongly influence their physico-chemical properties, resulting in novel electrical, optical, thermal and magnetic properties not present in their corresponding bulk counterparts. For example, nanostructures’ huge surface area to volume ratio make them not only more reactive and but uniquely applicable for next-generation devices, including for implantable CMOS. This large surface area is just one of the many factors that alter nanostructures’ biological interfaces. Other aspects include their size, shape, surface functionality, charge, composition (organic, inorganic or hybrid), aggregation, solubility. Because of the widely tunable sizes and compositions, ENs can dynamically modify under different biological and environmental conditions, thus limiting options for uniform nano-bio interactions and standardization.

Abstract:  The objective of this project is to establish a robust, rapid throughput and high-content screening platform to study biological interactions of ENs implemented on a beyond-CMOS substrate, including their potential toxicities due to their unique physico-chemical properties at the nano-scale. Towards this objective, we propose a multi-faceted exercise beyond the traditional singular-focus efforts involving a multi-disciplinary group of researchers from nanoengineering, nano-biophysics, nanochemistry and toxicology. An over-arching goal is to develop a new approach of scientific integration where nano-ESH is an integral part of EN design rather than a post facto add-on.

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